Neuroprotection in CNS diseases



Publisher: Marcel Dekker in New York

Written in English
Cover of: Neuroprotection in CNS diseases |
Published: Pages: 585 Downloads: 250
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Subjects:

  • Central nervous system -- Degeneration -- Chemoprevention.,
  • Central nervous system -- Pathophysiology.,
  • Central Nervous System Diseases -- physiopathology.,
  • Nerve Degeneration -- physiology.,
  • Neuroprotective Agents -- pharmacology.

Edition Notes

Includes bibliographical references and index.

Statementedited by P.R. Bär, M. Flint Beal.
ContributionsBar, Peter Rudolf, 1950-, Beal, M. Flint.
Classifications
LC ClassificationsRC365 .N478 1997
The Physical Object
Paginationxii, 585 p. :
Number of Pages585
ID Numbers
Open LibraryOL666850M
ISBN 100824798767
LC Control Number97012545

The pathophysiology of neurodegeneration in the central nervous system is complex and multifactorial in nature and yet to be fully understood. Broad-spectrum neuroprotective agents with multiple mechanisms of action rather than a single druggable target are, therefore, highly desirable. The main human estrogen, 17β-estradiol, can also be considered a neurosteroid as it forms de novo in the.   An NIH-funded phase 2 trial delivered positive 2a results this spring, but 2b data revealed in May showed the drug failed to lower levels of Alzheimer’s biomarkers in brain and spinal cord fluid. Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal loss over time, which can be expressed as a differential equation. It is a widely explored treatment option for many central nervous system (CNS. Frontiers Books allows users to browse, free of charge, through the pages of Frontiers e-books and e-magazines or download the entire pdf. You may also purchase hardcopy issues as well as other academic literature.

  Sleep well: Sleep disturbances are linked to Alzheimer’s disease and other neurodegenerative conditions, as well to neuropsychiatric disorders such as anxiety, stress, and depression. In most of. Neuroprotection and Remyelination after Autoimmune Demyelination in Mice that Inducibly Overexpress CXCL1. van der Meer P, Hesselgesser J, Jaffer S, Kolson DL, Albright AV, Gonzalez-Scarano F, Lavi E. CXCR3 expression in human central nervous system diseases. Neuroprotection within the nervous system protects neurons from apoptosis or degeneration, for example following a brain injury or as a result of chronic neurodegenerative diseases.. Currently, there is a broad interest in how apoptosis and neuroprotection affect the brain during development and after the onset of central nervous system (CNS) diseases (stroke, schizophrenia, Parkinson's disease).   Lithium Orotate NeuroProtection Part Two. by Jeffrey Dach MD. In part one, we discussed the differences between lithium carbonate, a prescription psychiatric drug, and a different version called lithium lithium carbonate, the lithium orotate is a safe nutritional supplement available without a prescription at the vitamin store. In Part Two, we review lithium as a neuro.

N2 - With an ever increasing aging population, age-related neurodegenerative disorders such as stroke and Alzheimer's disease (AD) are a major health concern in our society. AD is a debilitating disease affecting more than 35 million individuals worldwide, a figure that is expected to increase to over million by (Rosamond et al. ). The brain requires vast amounts of energy to carry out neurotransmission; indeed, it is responsible for approximately one-fifth of the body’s energy consumption. Therefore, in order to understand functions of brain cells under both normal and pathological conditions, it is critical to elucidate dynamics of intracellular energy. The mitochondrion is the key intercellular organelle that. Largazole is a potent class I selective histone deacetylase inhibitor prodrug with anticancer activity against solid tumors in preclinical models. Largazole possesses in vitro activity against glioblastoma multiforme (GBM) cells and sufficiently crosses the blood-brain barrier based on measurement of the active species, largazole thiol, to achieve therapeutically relevant concentrations in the.

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"CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain. " Indeed, in recent years, experimental study of putative neuroprotective agents p. "CNS neuroprotection" was a common subject of papers, symposia, and reviews during the previous "decade of the brain.

" Indeed, in recent years, experimental study of putative neuroprotective agents prompted clinical trials of numerous drug candidates in acute.

Given the very limited capacity of regeneration in the brain, protecting neurons that are on the brink of death is a major challenge for basic and clinical neuroscience, with implications for a broad spectrum of acute and chronic neurological and psychiatric diseases.

This book brings together leading experts from neurobiology, neurophysiology. COVID Resources. Reliable information about the coronavirus (COVID) is available from the World Health Organization (current situation, international travel).Numerous and frequently-updated resource results are available from this ’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus.

This book provides the latest findings on neuroprotection and neuroregeneration as potential therapeutic strategies for various eye diseases, namely, glaucoma, age-related macular degeneration (AMD), retinal detachment, and retinitis pigmentosa.5/5(1).

Diseases associated with metabolic dysfunction of brain, spinal cord, and nerves are called as Neuroprotection in CNS diseases book disorders. These disorders can be classified into three groups: neurotraumatic diseases, neurodegenerative diseases, and neuropsychiatric diseases.

Common neurotraumatic diseases are strokes, spinal cord injury, and traumatic brain injury. • The concept of neuroprotection is now important in many diseases that were once only treated symptomatically and in which a disease-modifying approach is desirable.

• Neuroprotective agents have an important role in the management of neurodegenerative disorders as well as acute insults such as CNS trauma, cerebral ischemia, and iatrogenic. Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders.

The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative Price: $ Neuroprotection has been placed on a firm scientific basis during the past decade due to an improved understanding of the molecular basis of neurological diseases and the knowledge that treatment of neurological disorders should not be merely symptomatic but preventative against the progression of the underlying disease, as well as regenerative.

Neuroprotection in Alzheimer’s Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management.

This book brings together the latest findings, both basic, and. Tahira Farooqui, Akhlaq A. Farooqui, in Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases, Neuroprotection.

Neuroprotection is defined as relative preservation of neuronal structure and/or function. It includes neuroprotective agents that protect against neuronal injury following acute diseases or neurodegeneration in the brain following chronic.

The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches.

The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and.

Caffeine is the most widely used psychostimulant in Western countries, with antioxidant, anti-inflammatory and anti-apoptotic properties. In Alzheimer's disease (AD), caffeine is beneficial in both men and women, in humans and animals. Similar effects of.

Many targets have been proposed for neuroprotection, but their efficacy in clinical trials has not been proven.

An enhanced understanding of neurobiology and novel technologies for CNS penetration pave the way for the development of effective therapies to prevent CNS damage. Title:Neuroprotection by (endo)Cannabinoids in Glaucoma and Retinal Neurodegenerative Diseases VOLUME: 16 ISSUE: 7 Author(s):Cinzia Rapino*, Daniel Tortolani, Lucia Scipioni and Mauro Maccarrone* Affiliation:Faculty of Veterinary Medicine, University of Teramo, Teramo, Faculty of Veterinary Medicine, University of Teramo, Teramo, Department of Medicine, Campus Bio.

Neuroprotection is becoming an increasingly recognized and important part of critical care and perioperative medicine. As human beings survive increasingly severe life-threatening injuries and complex surgical interventions, it has become clear that neurologic injury and dysfunction is a primary driver of long-term outcome and disability.

Title:Neurological Aspects of Medical Use of Cannabidiol VOLUME: 16 ISSUE: 5 Author(s):Carmen Mannucci, Michele Navarra, Fabrizio Calapai, Elvira V. Spagnolo, Francesco P. Busardò, Roberto D. Cas, Francesca M. Ippolito and Gioacchino Calapai* Affiliation:Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Department of Chemical.

Jain PharmaBiotech, Basel, Switzerland, has released a report titled "Neuroprotection for CNS Disorders: Commercial Opportunities". The report describes the role of neuroprotection in acute disorders such as stroke and injuries of the nervous system as well as in chronic diseases such as neurodegenerative disorders because many of the underlying mechanisms of damage to neural.

The proposed book is unique because it gives a comprehensive account of the neuroprotective and neurogenic effects of steroid and polypeptide hormones. Furthermore, new pharmacological approaches for treatment of neurodegenerative conditions are presented, based on the neuroprotective and neurogenic properties of natural and synthetic hormones.

Acute brain injury, whatever its cause, is associated with considerable short-term and long-term morbidity and mortality. In the USA it is estimated t fatalities arise as a result of traumatic brain injury (TBI) every year, and approximately million people live with TBI-related disabilities [].These figures are similar in the European Union, where an estimated million people.

Stanford Libraries' official online search tool for books, media, journals, databases, I. Applications of Nutraceuticals in Common Diseases and Disorders; 1 Nutraceuticals in CNS Diseases: Potential Mechanisms of Neuroprotection; Introduction; Polyphenols; Counteracting Oxidative Stress as a Mechanism of Neuroprotection; Direct Antioxidant.

Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection reviews current progress on neural heat shock proteins (HSP) in relation to neurodegenerative diseases (Part I), neuroprotection (Part II), ext- cellular HSP (Part III) and aging and control of life span (Part IV).

This open access book presents the roles and mechanisms of signal transduction triggered by nicotinic acetylcholine receptors (nAChRs) stimulation in neuroprotection against toxic effects of risk factors of neurodegenerative diseases.

Accumulating evidence suggests that nAChRs in the CNS play import. Excitoxic damage, metabolic imbalance, oxidative stress, and calcium influx are each capable of inducing cell death by both necrotic and apoptotic mechanisms.

If these various mechanisms contribute, separately and together, to neurodegeneration, then a rational strategy for treatment must be to search for ways of blocking the individual components of the cascade that leads to death. Heat Shock Proteins and the Brain: Implications for Neurodegenerative Diseases and Neuroprotection Softcover reprint of hardcover 1st ed.

Edition by Alexzander A.A. Asea (Editor), Ian R. Brown (Editor) ISBN ISBN Why is ISBN important. ISBN. This bar-code number lets you verify that you're getting exactly Format: Paperback. Free Online Library: Neuroprotection in Neurodegenerative Disease: From Basic Science to Clinical Applications.(Editorial, Report) by "Oxidative Medicine and Cellular Longevity"; Biological sciences Cell death Nervous system Degeneration Drug therapy Research Nervous system agents Complications and side effects Dosage and administration Nervous system diseases.

Stroke is a leading cause of death. Stroke survivors often suffer from long-term functional disability. This study demonstrated neuroprotective effects of BMS (BMS), a selective lysophosphatidic acid receptor 1 (LPA1) antagonist under clinical trials for lung fibrosis and psoriasis, against both acute and sub-acute injuries after ischemic stroke by employing a mouse model with.

Summary Most of the pathophysiological processes of neurodegenerative diseases share the aggregation of related proteins which is one of the hallmarks of the degenerative processes. Recent advances in the knowledge of these proteinopathies show that the same protein could contribute to a number of diseases, thus suggesting a common pathological process.

If this is so, specific instances. The recently published book Neuroprotection in Autism, Schizophrenia and Alzheimer’s Disease is dedicated to the understanding of neuroprotection in three key brain neurodegenerative or neurodevelopmental disorders: autism spectrum disorders (ASD), schizophrenia and Alzheimer’s disease (AD) as well as in some other neurodegenerative disorders.

The 70 kDa heat shock protein (HSP70) is a stress-inducible protein that has been shown to protect the brain from various nervous system injuries. It allows cells to withstand potentially lethal insults through its chaperone functions.

Its chaperone properties can assist in protein folding and prevent protein aggregation following several of these insults.

Introduction. Multiple sclerosis (MS) is an inflammatory, neurodegenerative and demyelinating autoimmune disease of the central nervous system (CNS) and is the most common cause of non-traumatic chronic neurologic disability [1–3].Neurodegeneration is the main cause of disease progression in MS patients []; however, the detailed mechanisms that mediate this neuronal injury/death are not yet.

Neuroprotection researchers are looking for ways to prevent or slow neuronal degeneration in conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. The mechanisms.The central nervous system (CNS) has a very limited capacity to regenerate, which makes it obligatory to search for new strategies for the treatment of CNS diseases (Tam et al., ).